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Major Contributions

Endothelium

  • Role of cytochrome P450-derived hyperpolarizing factors (EDHF) in endothelium-dependent vasodilatation in human, and consequences of its pharmacological restoration in cardio-metabolic diseases (PMID: 20083732 22412088 26022136 30885203 31436984)
  • Endothelial protective effects and reduction of heart failure by tyrosine phosphatase 1B inhibition (PMID: 22446161 17101854 24760754 27059805 29569957)
  • Dopamine and endothelial dysfunction in autosomal dominant polycystic kidney disease (PMID: 25029430 30607032)
  • Endothelial impact of antiphosphospholipid syndrome and thrombotic thrombocytopenic purpura (PMID: 25047402 27501520 30870459)

Valvulopathy

Heart Failure

  • Beneficial effects of pharmacological heart rate reduction in heart failure (PMID:14981003 22075752) and acute heart failure (PMID: 33471946)
  • Aldosterone signaling in heart failure (PMID: 26902493 29061727 29862614  29981797 29862614)
  • Treatment of heart failure by localized slow delivery of angiogenic or lymphangiogenic growth factors (PMID:21824923 26933083 30333526 )
  • Role of cardiac lymphatics and therapeutic lymphangiogenesis in myocardial infarction and heart failure (PMID: 26933083 30333526  32762908 32404007 32451732 35689481)
  • Patents

  • WO2020058201 - UTILISATION D'INHIBITEURS DE L'ACTIVITÉ PHOSPHATASE D'ÉPOXYDE SOLUBLE POUR LE TRAITEMENT DE MALADIES CARDIOMÉTABOLIQUES
  • WO2012119980 - PARTICULES CONTENANT UN FACTEUR DE CROISSANCE, ET UTILISATIONS DE CELLES-CI
  • WO2018178253 - COMPOSITIONS PHARMACEUTIQUES DESTINÉES À ÊTRE UTILISÉES DANS LE TRAITEMENT DE LA CALCIFICATION CARDIOVASCULAIRE
  • WO2020178441 - INHIBITEURS DE PROTÉINE NGAL
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