This spring 2022, we have 4 subjects open for candidates searching fora 3 year PhD fellowships in our laboratory. One will be financed by Inserm - Normandyregion (under the direction of Dr Antoine Ouvrard-Pascaud), and the three others will compete for funding from the Normandy doctoral school EdNBise in early July for start in September 2022.

• BRAKENHIELM: Regulation of Cardiac Immune Tolerance in Myocarditis (CarTol)

• MULDER: Metabolic remodeling in acute decompensated heart failure

• OUVRARD-PASCAUD: Involvement of aldosterone and benefits of treatment with a mineralocorticoid receptor antagonist on the cardiovascular consequences of yo-yo dieting inducing cyclic variations in body weight

• RICHARD/FRAINEAU: Pathophysiological role of epigenetic factor Ezh2 in cardiac metabolism modulation and identification as a therapeutic target for heart failure treatment

For more information, please contact us at:

Antoine.Ouvrard-Pascaud 'at' univ-rouen.fr

Ebba.Brakenhielm 'at' univ-rouen.fr

Paul.Mulder 'at' univ-rouen.fr

Sylvain.Fraineau 'at' univ-rouen.fr 

Notre UMR Inserm - Université de Rouen Normandie  EnVI 'Endothélium, Valvulopathies & Insuffisance cardiaque' recrute par voie de concours externe un assistant ingénieur (CDI) , disposant de compétences poussées en culture de cellules, co-cultures, culture en flux, et une maîtrise des techniques de PCR, Western Blot, cytométrie, tri cellulaire, … 
L'activité principale consiste à fournir un support aux activités de recherche pré-clinique menées dans l’unité autour du rétrécissement aortique (RA), en lien avec les Services de Cardiologie et de chirurgie cardiaque, dans le cadre de dispositifs d'excellence (RHU STOP-AS & FHU CARNAVAL) .Plus largement, l'assistant-ingénieur contribuera aux autres études du laboratoire portant sur des cultures de cellules (cellules endothéliales artérielles et lymphatiques , cellules immunitaires, ...)

Si vous êtes intéressé, consultez la page http://communaute-universitaire.univ-rouen.fr/liste-des-emplois-ouverts-au-concours-itrf-de-droit-commun-session-2022--663440.kjsp?RH=1383233146245 (poste Assistant ingénieur en expérimentation et instrumentation biologiques)

     Attention clôture des candidatures 28 avril 2022

In a recent study, directed by Pr Jeremy Bellien, the physiological role of the phosphatase domain of the bi-valent enzyme soluble epoxide hydrolase (sEH) was investigated. See M. Leuillier et al . Journal of Advanced Research 2022  https://doi.org/10.1016/j.jare.2022.03.004

Briefly, selective inactivation of the phosphatase domain of sEH was produced using a cre-lox KI strategy in rats,. This led to metabolic alterations, including decreased lysophosphatidic acid metabolism. In the setting of a high fat diet, lack of the phosphatase domain of sEH impacted both body weight gain and insulin sensitivity, which was improved as compared to wildtype animals that developed obesity and insulin resistance. The underlying mechanism involved increased energy expenditure by stimulation of brown adipose tissue thermogenesis. Further, KI rats exhibited enhanced basal cardiac mitochondrial activity and left ventricular contractility, and animals were protected against cardiac ischemia –reperfusion injury. 

This new study reveals that the phosphatase domain of sEH is a key player in energy and fat metabolism, which together with the hydrolase domain of sEH contributes to the regulation of cardiometabolic homeostasis.

Le Pr Hélène Eltchaninoff et son équipe du CHU de Rouen ont reçu le 15 novembre 2021, à Paris, le Prix Line Renaud-Loulou Gasté décerné par La Fondation pour la Recherche Médicale pour ses travaux sur le rétrécissement aortique.

A cette occasion Pr Eltchaninoff a participé à une emission sur le TAVI sur BFMtV.

Au meme temps, le service de Cardiologie du CHU Charles Nicol, dirigé par le Pr Eltchaninoff, a recu une visite de Mme Line Renaud et Monsieur Claude Chirac. (voir lien)

Our unit is proud to participate in the new exhibit dedicated to Health Research in Normandy organized by the Atrium. In this interactive and open exposition, notably dedicated to the role of the Microbiota in human health, you will also find examples and images of our research on the topic of Aortic Stenosis as well as on Heart Failure.

A la Recherche de Santé en Normandie pic.twitter.com/xTCoBAxzpD

— EnVI lab (@INSERMU1096) February 1, 2022