Our laboratory is welcoming applications from ambitious junior researchers with at least 4 years of research experience (including PhD studies) to apply for the competitive research funding from the postdoctoral research training network  The WINNINGNormandy Fellowship Programme | Région Normandie

Our laboratory is offering potential candidates a unique research environment, including  long-standing expertise in functional in vivo and ex vivo cardiovascular evaluations and access to our wide panel of relevant experimental models of cardiovascular diseases ranging from myocardial infarction, ischemia-reperfusion injury, chronic heart failure, acute heart failure, metabolic syndrome-induced cardiomyopathy, chronic kidney-disease induced cardiomyopathy, and sepsis-induced cardiomyopathy. Please contact our lead PIs for more details:

Paulus Mulder (expertise in HF models) paul.mulder[at]univ-rouen.fr ORCID

Ebba Brakenhielm (expertise in cardiac lymphatics) ebba.brakenhielm[at]univ-rouen.fr ORCID

Jeremy Bellien (expertise in endothelial dysfunction) jeremy.bellien[at]univ-rouen.fr ORCID

Nous avons pour la rentrée 2021 quatres potentielles offres de financements de thèse dans le laboratoire:

• Rôle de molécules de co-signalisation immunitaire lymphatiques en immuno-onco-cardiologie : myocardites induites par les inhibiteurs des points de contrôle immunitaires. 
• Impact délétère des particules d'usure des freins dans le syndrome métabolique. 
• Un Traitement par un Antagoniste du récepteur minéralocorticoïde permet-t-il de limiter une aGgravation de l’Insuffisance Cardiaque à fraction d’éjection préservée suite à l’Ovariectomie de souris en Syndrome Métabolique ? (TRAGICO-SMet).
•  Lactate de Sodium au cours du sepsis : (LactMet-Heart) impact métabolique sur la dysfonction cardio-vasculaire

voir plus

A recent experimental study, directed by D Guerrout, published in Front Mol Biosci , describes the beneficial cardiac impact, on both diastolic and systolic functions, of blocking soluble epoxide hydrolase (sEH) during chronic kidney disease (CKD) induced by 5/6 nephrectomy (Nx) in mice. These beneficial effects may be mediated by the prevention of endothelial dysfunction, independent from kidney preservation and antihypertensor effect. Thus, inhibition of sEH holds a therapeutic potential in preventing type 4 cardiorenal syndrome.

Coraline Heron, a 1st year PhD student in the laboratory, has together with our collaborator, David Godefroy (Inserm U1239), used light sheet imaging to reveal the delicate network of cardiac lymphatics in mice. Their work was awarded with a 1st Prize at the yearly FASEB BioArts competition in 2020.

https://www.faseb.org/Publications-and-Resources/BioArt/Current-Winners