Proudly presenting ERA4Health project HFpEF-DIVA Consortium (2024-2027):  Diverging HFpEF Phenotypes : patient-tailoreD targeting of anti-Inflammatory pathways to limit Ventricular and Atrial remodelling

Dr Ebba Brakenhielm Coordinator: EnVI Laboratory, INSERM UMR1096 Rouen, France	Dr Vanessa van Empel Partner 2:   Maastricht University Department of Cardiology, CARIM, Netherlands	Pr Arantxa González-Miqueo Partner 3: CIMA, Pamplona, Spain       .	Pr Elizabeth Jones Partner 4:  KU Leuven, Belgium	Dr Jean-Christophe Rain Partner 5: Hybrigenics SAS, Evry, France	Krista Bogaert Collaborator I:  Healthy Heart Fund, Leuven, Belgium

Read more: ERA4HEALTH Joint Action 

Twitter / X: #HFpEF_DIVA 

New review article on cardiac lymphatics published in ATVB

A post-doctoral position is available in our laboratory starting in April 2024. We are looking for a candidate with a recent PhD in Cell biology and/or analytical Biochemistry to join our cardiovascular research team. The proposed project will be led by Thomas Duflot (MCU-PH) in close collaboration with Jérémy Bellien (PU-PH), Ebba Brakenhielm (DR2 Inserm), Sylvain Fraineau and Valentin Platel (both MCF).

The position is funded through the European Innovation Council (EIC) Pathfinder Open  “MIMOSA” project (https://www.mimosa.cnrs.fr/), initiated in 2021. The project is based on multidisciplinary collaboration, involving physics, chemistry, biology, biomedicine and computational modelling. It is part of a European consortium that includes 3 research teams from UNIROUEN Normandy University: the EnVI UMR1096 laboratory, the GPM (Groupe de Physique des Matériaux) and CORIA (Complexe de Recherche Interprofessionnel en Aérothermochimie). The MIMOSA project brings together experts in light-matter interactions in the ultrafast regime, laser physics, atom probe tomography (APT) and biosample encapsulation. The ultimate goal to develop a novel high-resolution 4D microscopy platform based on a disruptive technology enabling high spatial resolution and chemical sensitivity analysis of biomaterial through ultrafast APT (THz-APT).

The recruited researcher will assume two main responsibilities:

1) synthesizing, purifying, and characterizing various nanosized biomaterials including mitochondrial fractions, proteins, lipoproteins, and extracellular vesicles for APT imaging.

2) assisting in the development and validation of an analytical method for analyzing sphingosine-1-phosphate (S1P). This part will build on ongoing international projects led by the EnVI laboratory including ANR PHASM (Bellien) and ANR CITE-LYMPH (Brakenhielm). Specifically, the researcher will investigate the role of S1P signaling in vascular endothelial cells, and its significance in maintenance of vascular and lymphatic barrier. The fellow will be responsible for the quantification of S1P in biological samples (from in vivo or in vitro models of cardiovascular disease) using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Additionally, the postdoc will conduct co-culture experiments involving endothelial cells and macrophages to study S1P release.

The INSERM UMR1096 EnVI laboratory is fully equipped for the proposed work, featuring an analytical chemistry platform situated within the Institute of Clinical Biology at Rouen University Hospital Charles-Nicolle. Additionally, state-of-the-art cell culture facilities are available at the EnVI research laboratory.

Key words: Sphingosine-1-Phosphate, Vascular Endothelial Cells, Macrophages, Angiogenesis, Lymphangiogenesis, Lymphatic endothelial cells, Extracellular Vesicles.

For further detail please see https://euraxess.ec.europa.eu/jobs/181622

Previous media articles on our research:

• Memory services for Pr Alain Cribier Décès du Professeur Alain Cribier - Université de Rouen Normandie (univ-rouen.fr),  Hommage au Professeur Alain Cribier (chu-rouen.fr)
• Highlight on chronic kidney disease by lab member Pr D Guerrot
• Highlight of our preclinical research in The Conversation
• Projet FHU CARNAVAL
• FASEB BIOART 2020
• RHU STOP-AS (@RHU_STOPAS) | FDNitter
• Projet RHU STOP-AS sélectioné
• Un reseau invisible au secours du coeur
• Prix Jean-Paul Binet
• Ma thèse en 180 secondes
• Prix "Don de soi -don de vie"
• Réseau ERA-CVD LYMIT-DIS
• Réseau FHU REMOD-VHF
• Helene Eltchaninoff, membre de la Fédération Hospitalo-Universitaire - Portail vidéo de l'Université de Rouen Normandie (univ-rouen.fr)