RESIST-HF ANR PRC 2018-2023
Acute decompensated heart failure (ADHF) represents a major therapeutic challenge. Although numerous well-established therapies are available in the clinic for chronic HF, the acute HF market has considerable unmet needs. Cardiac edema may be a key-player in this pathophysiological situation, and we hypothesize that loss of microvascular integrity in blood vessels and lymphatics contributes to cardiac edema in ADHF. We have previously shown that prevention of vascular hyperpermeability reduces cardiac edema acutely post-MI.
In this project, coordinated by Dr Stephane Germain (Collège de France) and in collaboration with Pr Bijan Ghaleh-Marzban (Mondor Biomedical Institute) and Pr Paul Mulder and Dr Ebba Brakenhielm at Inserm UMR 1096, we investigate, in our novel ADHF models, the contribution of microvascular leakage and/or lymphatic dysfunction to cardiac edema; and further determine if restoration of vascular integrity (Patent, Partner 1; Project coordinator) may reduce blood microvascular hyperpermeability, lymphatic dysfunction as well as cardiac edema and lead to improved cardiac functional recovery.
Our RESIST-HF project, focused on restoring microvascular integrity, will improve the understanding of ADHF mechanisms and may reveal new and efficient pharmacological strategies to improve patient outcome.